Pregabalin

Pregabalin is the active ingredient in Lyrica, which is an anticonvulsant and anti-anxiety medication that was developed as a successor to gabapentin. It can be used alone or in combination with other medications to treat chronic health issues like nerve pain and anxiety. Due to its unique, multimodal mechanism of action, this medication is also recommended in the treatment of various other conditions.

What Is Pregabalin Used For?

Despite increase in popularity, a consistent and frequent question associated with this medication is - what is pregabalin used for? Although this medication is primarily approved by the FDA for the treatment of nerve pain, seizures and generalised anxiety disorder, it also has several other uses. These include treating fibromyalgia, restless leg syndrome and chronic lower back pain. The following table describes these conditions further:

Scientists are still exploring the precise MOA of how pregabalin works to treat these conditions. However, this medication is thought to induce its effects in the following ways:

• For nerve pain, it is thought to relieve pain associated with conditions like postherpetic neuralgia, diabetic neuropathy and fibromyalgia by disrupting pain signals. This prevents pain messages from reaching the brain so less pain is felt.
• For seizures, this medication is thought to reduce unusual electrical activity in the brain and this helps prevent or reduce the severity of seizures.
• For anxiety, it is thought to reduce the release of certain chemicals in the brain called noradrenaline, glutamate and substance P. Overactivity of these chemicals can cause increased anxiety levels, but pregabalin anxiety capsules can counteract this.

What Are The Benefits Of Taking Pregabalin?

Pain associated with conditions like diabetic neuropathy and fibromyalgia can reduce the quality of a person's life. It can interfere with sleep and cause difficulty for a patient when participating in daily activities. As a result, patients with chronic pain conditions often experience emotional consequences like anxiety and depression.

Healthcare providers often recommend that patients buy pregabalin to reduce pain levels and decrease their overall sensitivity to discomfort. In addition, this medication has the ability to reduce anxiety and improve sleep. This tends to be highly beneficial as it can help a patient stay in a positive frame of mind and enjoy daily activities.

Pregabalin Dosage

The dosage of pregabalin depends on the condition being treated and it should be personalised for each patient. The usual adult pregabalin dose will vary from 150mg (half a pregabalin tablet) to 600mg (two tablets) per day, taken in 2 or 3 separate doses. The following are general recommended dosage instructions for certain health conditions:

• For nerve pain associated with diabetic peripheral neuropathy, the usual amount is a pregabalin 300mg dose (one pregabalin tablet) per day, divided into 3 separate doses.
• For postherpetic neuralgia, the recommended dose is 75mg to 150mg per day, in two separate doses. The dose may be increased to 150mg to pregabalin 300mg per day, three times a day.
• For fibromyalgia, begin treatment with 150mg per day in two separate doses and increase the dosage if necessary.

For patients who tolerate this medication well and benefit from treatment, a maximum daily pregabalin dose of 600mg per day may be administered in two or three separate doses. This medication should be taken with some water, on a full or empty stomach.

Pregabalin Side Effects and Warnings

Alcohol does not have a direct effect on the mechanism of action associated with this medication. However, it should be used with caution or avoided if you experience sleepiness or dizziness during treatment, as alcohol can make this side effect worse. Common, mild pregabalin side effects that may occur in more than 1 in 100 people include:

• Headaches
• Daytime sleepiness
• Nausea

If you buy pregabalin, there are steps that can be taken to mitigate or prevent these side effects. Drink enough water and get sufficient sleep to help prevent headaches. It is safe to take this medication with traditional painkillers. Daytime sleepiness can be reduced by taking a lower dose and it often helps to take this medication with food if you experience nausea during treatment.

The safety of this medication has not been established during pregnancy so its use should be avoided by pregnant women. The following patients should take extra care and use a lower dose, especially at the beginning of treatment:

• Patients with diabetes
• Patients with heart or kidney problems
• Elderly people

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